Foodborne fungus impairs intestinal wound healing in Crohn’s disease

Researchers at Washington University School of Medicine in St. Louis and the Cleveland Clinic have discovered that a fungus found in foods such as cheese and processed meats can infect sites of intestinal damage in mice and people with Crohn’s and prevent healing. Moreover, writes Tamara Bhandari of News Room treating infected mice with antifungal medication eliminates the fungus and allows the wounds to heal.

The findings, published March 12 in the journal Science, suggest that antifungal drugs and dietary changes are potential new approaches to improving intestinal wound healing and reducing symptoms of Crohn’s disease.

“We’re not suggesting that people stop eating cheese and processed meat; that would be going far beyond what we know right now,” said first author Umang Jain, PhD, an instructor in pathology & immunology at the School of Medicine. “What we know is that this foodborne fungus gets into inflamed, injured tissue and causes harm. We’re planning to perform a larger study in people to figure out if there’s a correlation between diet and the abundance of this fungus in the intestine. If so, it is possible dietary modulation could lower levels of the fungus and thereby reduce symptoms of Crohn’s disease.”

Crohn’s is a subtype of inflammatory bowel disease. As the name suggests, it is driven by chronic inflammation in the digestive tract and primarily treated with immunosuppressive medications. Crohn’s patients endure repeated cycles of gastrointestinal symptom flare-up and remission. During a flare, their digestive tracts are dotted with inflamed, open sores that can persist for weeks or even months.

To understand why intestinal ulcers take so long to heal in some people, Jain and senior author Thaddeus Stappenbeck, MD, PhD, formerly at Washington University and now at the Cleveland Clinic, studied mice whose intestines had been injured. By sequencing microbial DNA at the site of injury, they discovered that the fungus Debaryomyces hansenii was abundant in wounds but not in uninjured parts of the intestine.

People acquire the fungus through their food and drink, Jain said. D. hansenii is commonly found in all kinds of cheeses, as well as sausage, beer, wine and other fermented foods.

13 sick: Salmonella outbreak in France linked to raw milk cheese

Outbreak News Today reports that since November 2019, Public Health France reports investigating 13 cases of salmonellosis caused by Salmonella enterica serotype Dublin (S. Dublin) reported by the National Reference Center (CNR) of Salmonella (Institut Pasteur) due to the fact that the strains belong to the same genomic cluster.

The outbreak has been linked to the consumption of raw milk Morbier (cheese), purchased from different brands, health officials note.

The cases are spread over 7 regions of the country. Three cases died, though its not clear if the salmonellosis attributed to the deaths.

The analysis by the Directorate General of Food (DGAL) of cheese purchases from case loyalty cards made it possible to identify that the Morbiers bought by the cases came from the same supplier.

Udder Delights in Australia recalling cheese after E. coli found

Some of its most popular cheeses, including its 200g camembert and brie are being recalled. Dixie Sulda and Jessica Galletly of Adelaide Now report the SA company said there was no evidence the form of E.coli found was dangerous but it was recalling them as a precaution.

The cheeses are available from Coles and independent retailers in SA, Queensland, Victoria and WA. In NSW they also sell at Woolies and in Tasmania they are sold at independent retailers.

Udder Delights chef executive Sheree Sullivan said the team was “devastated” after small levels of the bacteria were found in some of the company’s white mould 200g cheeses.

“It is with a very heavy heart that Udder Delights is doing its first voluntary recall since we began 20 years ago,” Ms Sullivan said.

“The whole team is devastated, because we all just work so hard to create a really high quality product.

“You always learn some of your best lessons through disasters, and I never really understood what a voluntary recall was. It means you have a choice – do you want to recall or not? We decided as a business we wanted to be 100 per cent sure it was safe.

“It was great SA Health and Dairysafe confirmed it wasn’t a dangerous bacteria, which can sometimes be a little bit of sunshine in a dark cloud.”

Ms Sullivan would not speculate on what caused the contamination, but said they were working with SA Health and their quality assurance team to quickly resolve the issue.

255 sick from same Salmonella in American beef and Mexican soft cheese

What is already known about this topic?

Decreased susceptibility to azithromycin is rare among Salmonella serotypes that cause human infections in the United States. If antibiotic treatment is indicated, azithromycin is recommended as an oral therapy.

What is added by this report?

During June 2018–March 2019, an outbreak caused by multidrug-resistant Salmonella Newport with decreased susceptibility to azithromycin led to 255 infections and 60 hospitalizations. Infections were linked to Mexican-style soft cheese obtained in Mexico and beef obtained in the United States.

What are the implications for public health practice?

Whole genome sequencing can be used in Salmonella outbreak investigations for rapid prediction of antimicrobial resistance and can link cases to each other and to possible sources of infection.

Outbreak of salmonella Newport infections with decreased susceptibility to azithromycin linked to beef obtained in the United States and soft cheese obtained in Mexico—United States 2018-2019

23.aug.19

CDC

https://www.cdc.gov/mmwr/volumes/68/wr/mm6833a1.htm?s_cid=mm6833a1_e&deliveryName=USCDC_921-DM7382

‘Human cheese’ from celebrity skin bacteria

Of course Heston I-didn’t-sicken-550-people-wth-Norovirus Blumenthal would be vain enough to sign up to have cheese made from his skin – his groin area.

I’m a big fan of fermentations but am also a big fan of using knowledge and experience to improve on basic biological phenomena.

Bettina Makalintal of Vice writes that people have been fermenting for at least 9,200 years, and yet, not everyone’s convinced. The process requires bacteria, which can result in funky sights and smells, squicking some people out. Still, it’s safe to say that fermentation advocates have done a good job of turning people on to the magic of microbes: dry-aged beef is on high-end restaurant menus, and more and more people reap the illness flavor rewards of raw-milk cheese.

A new exhibit at London’s Victoria & Albert Museum called “Food: Bigger than the Plate” shows off not only a toilet made of cow manure and an edible water bottle, but also “human cheese.” The latter is made using human bacteria. And not just any human bacteria, but celebrity bacteria

Most cheese is made using starter cultures, bacteria that curdle the milk, and often, those starters come from a packet. For the V&A’s five “human cheeses,” however, that bacteria came from celebrities, who had their skin swabbed in the name of science and truly funky cheese: from baker and food writer Ruby Tandoh to chef Heston Blumenthal to Blur’s Alex James, a cheesemaker himself. (British rapper Professor Green and Suggs of the ska band Madness also contributed.) It’s “like a celebrity selfie in cheese form,” reads V&A’s blog.

The point, the museum says, is to challenge people’s “squeamishness” and to enhance “our appreciation of the microbial world.”

Raw is risky: Salmonella Dublin in raw milk cheese, France, 2015-16

Nontyphoidal Salmonella is a main cause of bacterial food-borne infection in Europe [1,2]. The majority of human infections is caused by a limited number of Salmonella serotypes among the 2,600 described to date [3,4]. Salmonella enterica serotype Dublin (S. Dublin) is particularly invasive in humans and more often leads to severe disease and higher mortality rates compared with other serotypes [47]. S. Dublin is host-adapted to bovines and is frequently isolated from cattle, with raw milk or raw-milk cheeses as a typical vehicle for food-borne outbreaks [8,9].

A picture taken on November 18, 2011 shows a Morbier cheese from France during the European bi-annual Eurogusto slow food festival in Tours, central France. Slow Food, whose symbol is a red snail, promotes food that is “good at a sensory level,” but also aims to educate people about traditional and wholesome means of production and defend biodiversity in the food supply. AFP PHOTO/ALAIN JOCARD / AFP PHOTO / ALAIN JOCARD

In 2012, a major S. Dublin outbreak occurred in France, with 103 cases linked to Saint-Nectaire (bovine raw-milk cheese) consumption [10,11]. In 2015, 34 S. Dublin cases were reported linked to the consumption of Reblochon (bovine raw-milk cheese) (data not shown; Santé publique France).

In France, the National Reference Center for Salmonella (NRC) and the French Agency for Food, Environmental and Occupational Health and Safety (ANSES) routinely collect and serotype human and non-human Salmonella isolates, respectively [1214], using the Kauffmann–White–Le Minor scheme [3]. The S. Dublin isolates collected are frequently susceptible to all antibiotics and show an indistinguishable pulsed-field gel electrophoresis (PFGE) pattern. To better distinguish S. Dublin isolates, multilocus variable-number tandem repeat analysis (MLVA) has recently been used for surveillance and outbreak investigations [11,15]. Moreover, whole genome sequencing (WGS) of Salmonella has been shown to discriminate between closely related isolates of S. Dublin [16,17].

On 18 January 2016, the French NRC reported to Santé publique France (SpFrance, the French national public health agency) an excess of S. Dublin infections across the country, with 37 S. Dublin isolates identified between mid-November 2015 and mid-January 2016, compared with 10 S. Dublin isolates during the same period in the two previous years. An outbreak investigation team with experts from SpFrance, NRC, ANSES and the French Directorate General for Food (DGAL) launched extensive epidemiological, microbiological and food investigations to confirm the outbreak, identify the vehicle of transmission and propose appropriate control measures.

Disentangling a complex nationwide salmonella Dublin outbreak associated with raw-milk cheese consumption, France, 2015 to 2016, 

Eurosurveillance

Aymeric Ung1,2,3Amrish Y. Baidjoe3,4,5Dieter Van Cauteren1Nizar Fawal5Laetitia Fabre5,Caroline Guerrisi6Kostas Danis1,2Anne Morand7Marie-Pierre Donguy7Etienne Lucas1,Louise Rossignol6Sophie Lefèvre5Marie-Léone Vignaud8Sabrina Cadel-Six8Renaud Lailler8,Nathalie Jourdan-Da Silva1,9Simon Le Hello5,9

 https://doi.org/10.2807/1560-7917.ES.2019.24.3.1700703

https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2019.24.3.1700703

EHEC in Germany: Cheese recalled

(Something may be lost in translation, which is where Pink Floyd comes in)

This was informed by the Federal office for consumer protection and food safety in Braunschweig, Germany, on Thursday.

It is the in several States product, marketed with the name “Petite Fleur herbs” (“Keiems bloempje met kruiden”) the date of minimum durability 08.11.2018 and the additional indication of “Lot 3603”, as a manufacturer Dischhof/Belgium has been specified.

In the worst case, kidney failure threatening, According to the Schwabacher company in an investigation of the image Verotoxin found E. coli in the cheeses, which are regarded as potential Ehec.

The editor recommends:

“From a consumption of the affected product is strictly not recommended”, the company said.

The Ehec can cause bloody diarrhoea and in severe cases lead to kidney failure, but there are also inconspicuous progressions. The severe course of a disease ends in about two percent of the cases fatal.

In the spring of 2011 had cost the largest German Ehec epidemic 53. In Germany, the disease occurs again and again, every year, about 1000 cases of Ehec are reported cases.

In the PCP Luke (15) died because no one recognized the symptoms – now, his mother warns all.

And this was the album of my grade 12.

1 dead, 25 sick: No fatal accident inquiry over girl’s E. coli death

BBC reports there will not be a fatal accident inquiry (FAI) into the death of a three-year-old girl from Dunbartonshire following an E. coli outbreak in 2016.

The Crown Office had previously said South Lanarkshire-based Errington Cheese would not face prosecution over the child’s death.

The firm’s Dunsyre Blue was named the most likely source of the outbreak.

The Crown Office said it had considered “all the relevant matters” before ruling out an FAI.

A total of 26 cases of the same strain of E. coli O157 were identified between July and September 2016 as a result of the outbreak, which left 17 people requiring hospital treatment.

A report published by Health Protection Scotland concluded in March 2017 that the source of the infection was consumption of an unpasteurised cows’ milk cheese.

Their incident management team found that potentially pathogenic E. coli were able to enter and survive the cheese production process at the food business.

However, Errington Cheese has repeatedly questioned the quality of the investigation and any suggestion that their product was responsible.

Going public, Salmonella-in-French-cheese-style: Morbier and Mont d’Or cheese behind 10 deaths in France, 2015-16

In a country where reporting foodborne illness is deemed unpatriotic an investigation by France Inter radio revealed that at least 10 people died in the Franche-Comté region in the east of France linked to two cheeses made from unpasteurized milk  in late 2015 and early 2016.

The investigation produced a document which showed that in January 2016 national health authorities had discovered an unusually high number of salmonella contaminations in France that was centred on Franche-Comté.

Five cheese making companies in the region, between them making 60 different brands, were later identified as being at the source of the contaminations that began in November 2015 and continued until April the following year.

In a way that is truly French in its description, those who died in the outbreak were old people who were physically weak or who suffered from another illness.

Jean-Yves Mano, the president of the CLCV consumer association, said he was surprised that a product recall had not been ordered of products that might have been infected with salmonella.

“We do not understand why a general alert was not issued by state officials, or at least information given on what precautions to take,” he told France Inter.

The state food agency, the Direction générale de l’alimentation (DGAL), said there were two reasons why a recall was not ordered.

The first was that it would have allegedly been very difficult to identify which exact brand of the cheeses were contaminated because there were a total of 60 that were produced in the cheese-making firms where the outbreak originated.

The second was that by the time the authorities found out where the outbreak had come from, the contaminated cheeses had already been consumed and the new batches in the cheesemakers’ premises were not infected.

“It is perhaps due to these two factors that this contamination was not in the media, even though all the data was public nothing was hidden,” said Fany Molin of the DGAL food agency.

That’s French-bureau-speak.

Go public: Further illnesses may be prevented; others learn; citizens may not come with torches demanding change; and it’s the right thing to do.

Going public: Early disclosure of food risks for the benefit of public health

Mar.17

NEHA, Volume 79.7, Pages 8-14

Benjamin Chapman, Maria Sol Erdozaim, Douglas Powell

http://www.neha.org/node/58904

Often during an outbreak of foodborne illness, there are health officials who have data indicating that there is a risk prior to notifying the public. During the lag period between the first public health signal and some release of public information, there are decision makers who are weighing evidence with the impacts of going public. Multiple agencies and analysts have lamented that there is not a common playbook or decision tree for how public health agencies determine what information to release and when. Regularly, health authorities suggest that how and when public information is released is evaluated on a case-by-case basis without sharing the steps and criteria used to make decisions. Information provision on its own is not enough. Risk communication, to be effective and grounded in behavior theory, should provide control measure options for risk management decisions. There is no indication in the literature that consumers benefit from paternalistic protection decisions to guard against information overload. A review of the risk communication literature related to outbreaks, as well as case studies of actual incidents, are explored and a blueprint for health authorities to follow is provided.

Washed rind cheeses from France recalled in Australia

The NSW Food Authority advises Washed Rind Pty Ltd has recalled a variety of cheeses made in France from IGA and Supa IGA in NSW, independent retailers in QLD and ACT, Foodworks and independent retailers in VIC, Foodlands IGA and independent retailers in SA and IGA, Supa IGA and independent retailers in WA due to potential Listeria monocytogenes contamination.

Product details:

Saint Simeon 200g, Plastic container, Best before 08-04-201

Brie de Nangis 1kg, Wrapped in cheesepaper/plastic and set in ½ wooden box, Best before 08-04-2018

Le Vignelait Brillat Savarin 500g, Plastic container, Best before 8-04-2018

Coulommiers Truffe 800g, Wrapped in cheesepaper/plastic and set in ½ wooden box, Best before 08-04-2018 and 22-04-2018

Le Coulommiers 500g, Wrapped in cheesepaper/plastic and set in ½ wooden box, Best before 08-04-2018 and 22-04-2018

Brie de Brie Pasteurise 2.8kg, Wrapped in cheesepaper/plastic and set in ½ wooden box, Best before 08-04-2018 and 22-04-2018