CDC’s Romaine clapback

Maybe it’s Californian Romaine, maybe not, but there looks to be some contradiction between messages from FDA’s Scott Gottlieb and CDC’s Director, Robert Redfield.

Redfield announced this after Gottlieb’s tweets indicating that the source of illnesses is likely California.

CDC continues to investigate a multistate outbreak of E. coli O157 infections linked to romaine lettuce. We understand this outbreak is of concern to many Americans – especially with so many gathering for meals this Thanksgiving week. CDC’s disease detectives are working with federal regulatory partners to investigate and determine the source of contamination as quickly as possible. We will continue to provide more information as it becomes available. The good news is we were able to detect and identify the outbreak quickly through our disease surveillance system, which can prevent further illness.

However, until we know more, it’s crucial that Americans continue to follow the guidance that CDC issued. There are no exceptions – all romaine lettuce must be discarded, regardless of brand, type, or if it is in a mixture. We also continue to urge people to follow our tips to help prevent E. coli illness. In addition, we remind clinicians that antibiotics are not recommended for patients in whom E. coli O157 is suspected until diagnostic testing rules out this infection.

FDA’s Gottlieb says Romaine likely came from California (other regions might be off the hook)

Scott Gottlieb, FDA Commissioner took to the Twitter this morning while many were buying TVs and Himalayan salt lamps to talk about the Romaine-linked E. coli O157 outbreak.

I imagine there’s lots of pressure out there to lift the blanket statement from CDC to avoid all Romaine. Especially if the dates of harvest/transition from one location to another make it so it’s not likely that lettuce from certain regions would be linked to the outbreak.

Some sort of identification is great – because how would a consumer know what to ask about or how to figure out the source without it.

 

 

Flour power: NEJM paper on 2016 outbreak

A couple of weeks ago Duncan Hines brand cake mixes were recalled because of Salmonella. Maybe it was the flour. Flour comes from dried wheat that’s milled and not heat treated (because it messes with the gluten). As the Salmonella dries out it gets hardier and survives for months (or longer).

In 2016 pathogenic E. coli (both O121 and O26 serogroups) was the culprit in another raw flour outbreak. The good folks involved with that investigation (Crowe and colleagues) published their findings this week in the New England Journal of Medicine.

The outbreak began in December 2015 and lasted through to September 2016. Fifty-six cases in 22 states were identified.

The biggest takeaway for me was this (such a great explanation of how an investigation works):

Open-ended telephone interviews then were conducted with 10 patients, all of whom stated that they baked frequently or regularly consumed home-baked foods. Five of the patients recalled baking during the week before illness onset, and 3 others reported thatthey might have baked during that period. Of the 5 case patients who remembered baking, 4 reported eating or tasting homemade batter or dough, 3 of whom used brand A flour. The fourth used either brand A or another brand. Two of the patients (a resident of Colorado and a resident of Washington) still had the bags of brand A flour that they had used in the week before illness onset.

Shortly thereafter, state investigators identified 3 ill children who had been exposed to raw flour at restaurants in Maryland, Virginia, and Texas. Restaurant staff had given them raw dough to play with while they waited for their food to be served.

Folks in the media or the hockey arena often ask how these outbreaks get solved. This is how – lots of interviewing, hypothesis generating and then a case-case or case-control analysis. It’s part detective work, part statistics and all science. Sometimes the interviews are messy but this one shows what happens when it works.

Trace-back investigation of the two bags of brand A flour collected from patients in Colorado andWashington revealed that the flour from Colorado was unbleached all-purpose flour manufactured on November 14, 2015, and the flour from Washington was bleached all-purpose flour manufactured on November 15, 2015. The two bags were produced in the same facility. The flour that was used in the raw dough given to the children exposed in the Maryland, Virginia, and Texas restaurants also was from this facility, as was flour from three additional bags collected from case patients residing in Arizona, Califor- nia, and Oklahoma.

Romaine again: leafy green linked to illnesses in Canada and US

I’m not really a salad fan. I know it’s not cool to admit that, but I love lots of other types veggies (so don’t email me about my nutrition)>

One of the salads I can handle (although it’s not my favorite) is Caesar – Romaine with a yogurt-based garlic, lemon and olive oil mixture with some asiago and bacon is doable.

Caesar and Romaine is off the menu right now after E. coli O157 has been linked to 18 cases in Canada and 32 cases in the U.S. 

Fascinating part of this one is (as PHAC states), 

Laboratory analysis indicates that the illnesses reported in this outbreak are genetically related to illnesses reported in a previous E. coli outbreak from December 2017 that affected consumers in both Canada and the U.S. This tells us that the same strain of E. coli is causing illness in Canada and the US as was seen in 2017 and it suggests there may be a reoccurring source of contamination. Investigators are using evidence collected in both outbreaks to help identify the possible cause of the contamination in these events.

CDC notes that this outbreak is not linked to the one that was traced to Yuma.

Public health investigators are using the PulseNet system to identify illnesses that may be part of this outbreak. PulseNet is the national subtyping network of public health and food regulatory agency laboratories coordinated by CDC. DNA fingerprinting is performed on E. coli bacteria isolated from ill people by using techniques called pulsed-field gel electrophoresis (PFGE) and whole genome sequencing (WGS). CDC PulseNet manages a national database of these DNA fingerprints to identify possible outbreaks. WGS gives a more detailed DNA fingerprint than PFGE. WGS performed on E. coli bacteria from ill people in this outbreak showed that the strains were closely related genetically. This means that the ill people were more likely to share a common source of infection.

As of November 20, 2018, 32 people infected with the outbreak strain of E. coli O157:H7 have been reported from 11 states. A list of the states and the number of cases in each can be found on the Map of Reported Cases page.

Illnesses started on dates ranging from October 8, 2018 to October 31, 2018. Ill people range in age from 7 to 84 years, with a median age of 24. Sixty-six percent of ill people are female. Of 26 people with information available, 13 (50%) were hospitalized, including one person who developed hemolytic uremic syndrome, a type of kidney failure. No deaths have been reported.

Illnesses that occurred after October 30, 2018, might not yet be reported due to the time it takes between when a person becomes ill with E. coli infection and when the illness is reported. This takes an average of two to three weeks.

Ongoing outbreak and reoccurring source makes a recall (and no Romaine consumption) a good idea for now.

Over 80 outbreaks linked to leafy greens since 1995 – is pretty good justification.

Norovirus is hard to get rid of, especially in a shelter

I’m still here, just like norovirus.

I can’t really imagine what it’s like to have your community and homes destroyed by fire. I really struggle to find the words or feelings to describe what residents of California are going through. Viewing the social media posts and videos of folks fleeing the flames is emotional.

A few years ago an outbreak linked to a Denver homeless shelter made it into the barfblog new and notable category. Forty folks who depended on the emergency food were affected by violent foodborne illness symptoms after eating donated turkey. Fourteen ambulances showed up and took those most affected to area hospitals.

Getting into a shelter or temporary housing because of the fires and then acquiring norovirus is a terrible situation.

Butte County Public Health Department says that over 140 individuals housed in a Camp Fire shelters likely have norovirus. 

Since the shelters opened to house Camp Fire evacuees, 145 people have been sick with vomiting and/or diarrhea. As of Wednesday evening, there were 41 people experiencing symptoms at the following shelters:

Neighborhood Church: 179 total evacuees at the shelter, 21 currently experiencing illness

Oroville Nazarene Church: 352 total evacuees at the shelter, 10 currently experiencing illness

Butte County Fairgrounds: 142 total evacuees at the shelter, 9 currently experiencing illness

East Avenue Church: 200 total evacuees at the shelter, 1 currently experiencing illness

The number of sick people is increasing every day. Twenty-five people have been to the hospital for medical support. Staff serving the shelters have also been sick.

Norovirus can quickly go through a food shelter with many people living in close quarters. Once the virus is there, it is hard to get rid of.

As one friend of the blog posted on social media, having norovirus and using a public bathroom to deal with the symptoms must be particularly degrading.

This one is weird, 21 boxes: Salmonella causes limited Cap’n Crunch cereal recall

I’ve seen a lot of recalls, this is the first time I remember seeing only 21 boxes distributed to five specific stores. I’d like to know the back story on this one (maybe some avid barfblog readers can help).

The Quaker Oats Company, a subsidiary of PepsiCo, Inc., today announced a voluntary recall of a small quantity of Cap’n Crunch’s Peanut Butter Crunch cereal due to the potential presence of Salmonella. While the potentially affected product only reached five specific Target stores and is limited to 21 boxes of one variety with two Best Before Dates, Quaker is initiating the voluntary recall to protect public health.

The recall was initiated as the result of a routine sampling program by the company, which revealed the finished product may contain bacteria.

The product being recalled was distributed in limited quantities only to the five Target stores listed below. This recall only includes 21 outstanding boxes purchased after Nov 5.

This is some Willy Wonka golden ticket type stuff. I wonder if this was a market withdrawal that happened, except all but 21 boxes were pulled before sales. On the shelf quick, than off the shelf. Except for 21.

 

Posting restaurant grades is a good thing; does it make food safer? It’s hard to tell

I’ve long been a fan of posting restaurant inspection scores, grades, happy faces, whatever. The philosophy I subscribe to is that the inspection work is done with public money and the public should have access to the results. Whether the info is posted on the door, or a website, it should be accessible.

For a while lots of folks have wondered whether the posting matters, public health wise. I want to believe it does, but I’m still not sure.

The biggest issue in real life experimentation and hypotheses is that there are lots of other factors that could lead to an outcome. And if the outcome you’re looking for is reduction in Salmonella illnesses, you likely can find it if you look. Like Melanie Firestone and Craig Hedberg did in their EID paper that was released this week.

But I’m not convinced that less Salmonella was a result posting grades alone. And I don’t think they are either, since Firestone and Hedberg  highlight the other factors in their limitations:

First, this was a quasiexperimental, ecologic study that represents an association and not a causal relationship. Second, the NYC restaurant letter grade program involved multiple changes to sanitation enforcement in addition to letter grade posting; changes included inspection frequency, greater risk for fines, improvements to online resources, and additional training opportunities.. As a result, we could not determine which factors contributed the most to the reduction in Salmonella infections.

It’s good stuff, we need more data on these things. Posting grades is good, and absolutely should be done. So is increasing consequences and oversight – but how much each factor matters is still unknown. And what about other pathogens like norovirus and pathogenic E. coli?

Corn-stuff may increase E. coli O157 in cattle

Inclusion of distillers’ grains (DGs) has been associated with
increased prevalence of Escherichia coli O157:H7 in cattle housed in
research settings. Our objective was to quantify the relationship
between inclusion of DGs in commercial feedlot rations and the burden
of E. coli O157.

A convenience sample of 10 feedlots was enrolled based on DG use in finishing diets; 1 cohort included 5 feedlots in which DGs were greater than 15% of the dietary dry matter and the other cohort consisted of 5 feedlots at a concentration less than 8%. 

Sampling occurred at each feedlot on four occasions at ∼6-week
intervals. At each feedlot visit, 4 pens of cattle within 3 weeks of
slaughter were selected and 24 freshly voided fecal pats were sampled.

Ten-gram samples were enriched in 90 mL of modified tryptic soy broth with novobiocin (20 mg/L) for 14 h at 42°C. Enrichments were subjected to immunomagnetic separation, plating onto chromogenic agar with novobiocin (5 mg/L) and potassium tellurite (2.5 mg/L), incubation for 18 h at 37°C, and latex agglutination of morphologically typical colonies. E. coli O157 was recovered from 16.7% of 3840 samples.

Adjusted prevalence was 14.3% after controlling for within-feedlot and
within-pen clustering. Prevalence during each sampling period was
19.9% (round 1), 21.0% (round 2), 14.1% (round 3), and 11.7% (round
4). Prevalence varied between cohorts, but this difference varied over
time (p = 0.06). Among those with greater than 15% of the diet as DGs, prevalence was greater than those with less than 8% inclusion for all rounds of sampling (p < 0.01). Averaged across time, prevalence was 23.9% and 9.4% for those with greater than 15% and those with less than 8% of DGs, respectively. While observational, these data provide real-world support of reports of increased E. coli O157:H7 burden associated with DG use in cattle diets.

Corn-based distillers’ grains in diets for feedlot cattle are associated with the burden of Escherichia coli O157 in feces

Foodborne Pathogens and Disease 15:298-405

Evan Chaney, Rebecca Maloney, Bradley J. Johnson, J. Chance Brooks, Mindy M. Brashears, and Guy H. Loneragan.

FDA warns of honey-filled pacifiers after links to 4 cases of infant botulism

Tragic stories around infant botulism have popped up over the past couple of years and, as a dad, reading them is like a gut-punch.

In 2011, infant Amanda Zakrzewski was diagnosed with infant botulism and had to undergo 9 days of antitoxin treatment in hospital. Amanda wouldn’t eat, her eyes glassed over and she wasn’t able to suckle due to the paralysis the botulinum outgrowth caused. The result was months of rehab.

Also in 2011, 16-week-old Logan Douglas was temporarily blinded and paralyzed from infant botulism. He fully recovered after six months, but at one point the illness was so severe that doctors had discussed turning off life support systems as the toxin was attacking his body.

Logan’s illness was linked to honey that his pacifier was dipped into.

Kinda like the four infants from Texas whom FDA says have acquired the terrible illness from pacifiers filled with honey.

The FDA is reminding parents and caregivers not to give honey to infants or children younger than one year of age. This includes pacifiers filled with or dipped in honey.

The FDA has received reports from the state of Texas that four infants have been hospitalized with botulism. All four infants had used pacifiers containing honey. These pacifiers were purchased in Mexico, but similar products also appear to be available in the U.S. through online retailers.

Walkerton E. coli O157 pain lingers after 18+ years

It’s the helicopters.

We live near the publically-funded Princess Alexandria hospital.

A helicopter flies over our house a couple of times a day bringing some victim from the outback or the coast.

The state of Queensland is really, really big.

It reminds me of my Walkerton-resident friend, Jim, and what he went through in the aftermath of the E.coli O157 outbreak in drinking water that killed seven and sickened 2,500 in the town of Walkerton, population 5,000.

Jim knew that every helicopter was someone dead or dying being flown to the medical center in London, Ontario (that’s in Canada, like Walkerton).

I think of Jim and the victims every time a chopper goes past.